Synthesis and Anti-Angiogenic Activity of Cortistatin Analogs
نویسندگان
چکیده
منابع مشابه
Synthesis and anti-angiogenic activity of cortistatin analogs.
Analogs of cortistatins, a series of anti-angiogenic compounds isolated from the Indonesian marine sponge Cortisium simplex, were synthesized from estrone by using the Suzuki-Miyaura coupling reaction as the key step. The estrone-isoquinoline hybridized compound showed selective inhibitory activity against the proliferation and VEGF-induced migration of HUVEC.
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ژورنال
عنوان ژورنال: Bioscience, Biotechnology, and Biochemistry
سال: 2008
ISSN: 0916-8451,1347-6947
DOI: 10.1271/bbb.80562